Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Statistical Measurement [Domain]
Statistical Measurement [Domain]
Schedule of Debt Securities, Available-for-Sale
Debt Securities, Available-for-Sale [Table Text Block]
Award Timing Predetermined
Award Timing Predetermined [Flag]
Asset Class [Axis]
Asset Class [Axis]
Entity File Number
Entity File Number
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Tabular List, Table
Tabular List [Table Text Block]
License And Collaboration Agreement
License And Collaboration Agreement [Member]
License And Collaboration Agreement
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Accounts payable
Increase (Decrease) in Accounts Payable
Share-based payment arrangement
Share-Based Payment Arrangement [Member]
License
License [Member]
Shares withheld for taxes for vesting of restricted stock units
Share-Based Payment Arrangement, Decrease for Tax Withholding Obligation
Trading Arrangements, by Individual
Trading Arrangements, by Individual [Table]
Class of warrant or right, outstanding (in shares)
Class of Warrant or Right, Outstanding
Net loss per share attributable to common stockholders, basic (in dollars per share)
Earnings Per Share, Basic
Adjustment to Compensation:
Adjustment to Compensation [Axis]
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Named Executive Officers, Footnote
Named Executive Officers, Footnote [Text Block]
Common Stock Warrants
Common Stock, Warrants [Policy Text Block]
Common Stock, Warrants
Total shares of authorized common stock reserved for future issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Tenacia
Tenacia [Member]
Tenacia
Schedule of Segment Reporting Information, by Segment
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Issuance of common stock under employee stock purchase plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Summary of Common Stock Reserved For Future Issuance
Schedule Of Common Stock Reserved For Future Issuance [Table Text Block]
Schedule Of Common Stock Reserved For Future Issuance
Transaction price
Revenue, Remaining Performance Obligation, Amount
Debt securities, available-for-sale, accumulated gross unrealized losses, current, before tax
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, Current, before Tax
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, Current, before Tax
Adjustment to Compensation, Amount
Adjustment to Compensation Amount
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Shares reserved for exercise of outstanding stock options
Outstanding stock options
Share-Based Payment Arrangement, Option [Member]
Award Timing MNPI Disclosure
Award Timing MNPI Disclosure [Text Block]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Total stockholders’ equity
Beginning balance
Ending balance
Equity, Attributable to Parent
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-Sale [Table]
Insider Trading Policies and Procedures [Line Items]
Total stock-based compensation expense
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Common stock, authorized (in shares)
Common Stock, Shares Authorized
Issuance of common stock (in shares)
Stock Issued During Period, Shares, New Issues
Current assets:
Assets, Current [Abstract]
Canceled or forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Total liabilities and stockholders’ equity
Liabilities and Equity
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Fair Value, Recurring
Fair Value, Recurring [Member]
April 2024 Follow-On Offering
April 2024 Follow-On Offering [Member]
April 2024 Follow-On Offering
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Cover [Abstract]
Cover [Abstract]
Cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Maximum
Maximum [Member]
General and administrative
General and Administrative Expense [Member]
Exercisable (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Securities, unrealized loss position, fair value
Debt Securities, Available-for-Sale, Unrealized Loss Position
Shares reserved for vesting of restricted stock units
Unvested restricted stock units
Restricted Stock [Member]
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Total Compensation Amount
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Adjustment to Non-PEO NEO Compensation Footnote
Adjustment to Non-PEO NEO Compensation Footnote [Text Block]
Pay vs Performance Disclosure [Line Items]
Class of Warrant or Right [Axis]
Class of Warrant or Right [Axis]
Debt securities issued by US. government agencies
US Government Agencies Debt Securities [Member]
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Non-Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated [Flag]
Entity Shell Company
Entity Shell Company
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Relutrigine
Relutrigine [Member]
Relutrigine
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Company Selected Measure Amount
Company Selected Measure Amount
Award Timing MNPI Considered
Award Timing MNPI Considered [Flag]
Sale of stock, volume-weighted average price, premium
Sale Of Stock, Volume-Weighted Average Price, Premium
Sale Of Stock, Volume-Weighted Average Price, Premium
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Ulixacaltamide
Ulixacaltamide [Member]
Ulixacaltamide
Name
Measure Name
Within one year
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One
Summary of Stock-Based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Operating lease liabilities
Operating Lease, Liability, Current
Document Fiscal Period Focus
Document Fiscal Period Focus
Award Timing Method
Award Timing Method [Text Block]
Award Type [Axis]
Award Type [Axis]
Total assets
Assets
Issuance costs from at-the-market offering included in accrued expenses
Stock Issuance Costs Incurred But Not Yet Paid
Stock Issuance Costs Incurred But Not Yet Paid
Trading Symbol
Trading Symbol
Vested (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Recently Enacted Tax Legislation
Income Tax, Policy [Policy Text Block]
Entity Address, City or Town
Entity Address, City or Town
Cash flows from operating activities:
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Other segment expenses
Segment Reporting, Other Segment Item, Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Statement of Income Location, Balance [Domain]
Statement of Income Location, Balance [Domain]
Compensation Actually Paid vs. Other Measure
Compensation Actually Paid vs. Other Measure [Text Block]
Entity Emerging Growth Company
Entity Emerging Growth Company
Warrant
Warrant [Member]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Beginning balance (in shares)
Ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member]
Level 2
Fair Value, Inputs, Level 2 [Member]
Insider Trading Policies and Procedures Not Adopted
Insider Trading Policies and Procedures Not Adopted [Text Block]
Unvested Restricted Stock Units
Unvested Restricted Stock Units [Member]
Unvested Restricted Stock Units
Common stock, outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
Plan Name [Axis]
Plan Name [Axis]
PEO
PEO [Member]
Accrued personnel-related expenses
Accrued Personnel Related Expenses Current
Accrued Personnel Related Expenses, Current.
Changes in operating assets and liabilities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Issuance of common stock upon exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member]
Nature of Operation, Product Information, Concentration of Risk [Table]
Nature of Operation, Product Information, Concentration of Risk [Table]
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Proceeds from issuance of equity
Proceeds from Issuance or Sale of Equity
Accumulated Deficit
Retained Earnings [Member]
January 2024 Public Offering
January 2024 Public Offering [Member]
January 2024 Public Offering
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Summary of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Restatement Determination Date
Restatement Determination Date
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Cash, cash equivalents and restricted cash, beginning of period
Cash, cash equivalents and restricted cash, end of period
Total cash, cash equivalents and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Income Statement [Abstract]
Income Statement [Abstract]
Sale of Stock [Domain]
Sale of Stock [Domain]
Available-for-sale marketable securities
Investments, Fair Value Disclosure
Preferred stock, issued (in shares)
Preferred Stock, Shares Issued
Pension Adjustments Service Cost
Pension Adjustments Service Cost [Member]
Product and Service [Domain]
Product and Service [Domain]
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Axis]
Debt securities, available-for-sale, amortized cost, current
Debt Securities, Available-for-Sale, Amortized Cost, Current
Accrued external research and development expenses
Accrued External Research And Development Expenses Current
Accrued External Research And Development Expenses, Current.
Cash, cash equivalents, and short-term investments
Cash, Cash Equivalents, and Short-Term Investments
Restatement does not require Recovery
Restatement Does Not Require Recovery [Text Block]
Pre-funded Warrants
Pre-funded Warrants [Member]
Pre-funded Warrants
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Non-cash operating lease expense
Operating Lease, Right-of-Use Asset, Periodic Reduction
Compensation Actually Paid vs. Company Selected Measure
Compensation Actually Paid vs. Company Selected Measure [Text Block]
City Area Code
City Area Code
Award Timing, How MNPI Considered
Award Timing, How MNPI Considered [Text Block]
All Trading Arrangements
All Trading Arrangements [Member]
Equity Awards Adjustments, Footnote
Equity Awards Adjustments, Footnote [Text Block]
Total Shareholder Return Vs Peer Group
Total Shareholder Return Vs Peer Group [Text Block]
Weighted average remaining contractual term vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Accrued expenses
Total accrued expenses
Accrued Liabilities, Current
Beginning balance (in shares)
Ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Cash flows from investing activities:
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
General and administrative
General and Administrative Expense
Unrecognized compensation expense related to unvested stock based awards
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Pay vs Performance Disclosure
Pay vs Performance Disclosure [Table]
January 2024 Follow-On Offering
January 2024 Follow-On Offering [Member]
January 2024 Follow-On Offering
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Related Party Transactions [Abstract]
Related Party Transactions [Abstract]
Preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Subsequent Event
Subsequent Event [Member]
Schedule of Fair Value of Stock Option Awards on the Grant Date Using the Black-Scholes Option Valuation Model
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Equity Valuation Assumption Difference, Footnote
Equity Valuation Assumption Difference, Footnote [Text Block]
PEO Total Compensation Amount
PEO Total Compensation Amount
Gain (loss) on available-for-sale securities
Gain (Loss) on Investments
Depreciation expense
Depreciation expense
Depreciation
Vested and expected to vest (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Money market funds
Money Market Funds [Member]
Equity Components [Axis]
Equity Components [Axis]
Nature of the Business
Nature of Operations [Text Block]
Non-Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Follow-On Offering
Follow-On Offering [Member]
Follow-On Offering
Number of performance obligations
Number Of Performance Obligations
Number Of Performance Obligations
Other Performance Measure, Amount
Other Performance Measure, Amount
Weighted Average Exercise Price per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Entity Address, State or Province
Entity Address, State or Province
Antidilutive Security, Excluded EPS Calculation [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Sale of stock, value transferred
Sale Of Stock, Value Transferred
Sale Of Stock, Value Transferred
Total current liabilities
Liabilities, Current
Over-Allotment Option
Over-Allotment Option [Member]
Operating lease liabilities
Increase (Decrease) in Operating Lease Liabilities
Increase (Decrease) in Operating Lease Liabilities.
Vesting of restricted stock awards (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Individual:
Individual [Axis]
Restricted cash
Restricted Cash
Research and development
Research and Development Expense [Member]
Net cash provided by (used in) investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member]
Document Fiscal Year Focus
Document Fiscal Year Focus
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Forgone Recovery, Explanation of Impracticability
Forgone Recovery, Explanation of Impracticability [Text Block]
Entity Interactive Data Current
Entity Interactive Data Current
Plan Name [Domain]
Plan Name [Domain]
Weighted-average period (in years)
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Issuance of common stock from exercise of pre-funded warrants (in shares)
Stock Issued During Period, Shares, Exercise Of Warrants
Stock Issued During Period, Shares, Exercise Of Warrants
Issuance of common stock upon exercise of stock options (in shares)
Exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Aggregate intrinsic value exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Segment Information
Segment Reporting Disclosure [Text Block]
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Table]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Class of warrants or rights, exercised (in shares)
Class Of Warrants Or Rights, Exercised
Class Of Warrants Or Rights, Exercised
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
UCB
UCB [Member]
UCB
Other debt securities
Other Debt Obligations [Member]
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Total Shareholder Return [Text Block]
Fair Value, Recurring and Nonrecurring [Table]
Fair Value, Recurring and Nonrecurring [Table]
October 2025 Public Offering
October 2025 Public Offering [Member]
October 2025 Public Offering
Proceeds from collaboration arrangement
Proceeds From Collaboration Arrangement
Proceeds From Collaboration Arrangement
Other non-current assets
Other Assets, Noncurrent
Entity Central Index Key
Entity Central Index Key
PEO Name
PEO Name
Cash equivalents, accumulated gross unrealized losses, current, before tax
Cash Equivalents, Accumulated Gross Unrealized Loss, Current, Before Tax
Cash Equivalents, Accumulated Gross Unrealized Loss, Current, Before Tax
Collaboration revenue
Revenues
Sale of stock, consideration received on transaction
Sale of Stock, Consideration Received on Transaction
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member]
Supplemental disclosures of non-cash activities:
Supplemental Cash Flow Elements [Abstract]
Outstanding Aggregate Erroneous Compensation Amount
Outstanding Aggregate Erroneous Compensation Amount
Arrangement Duration
Trading Arrangement Duration
Schedule of Segment Reporting Information, by Segment [Table]
Schedule of Segment Reporting Information, by Segment [Table]
Segments [Axis]
Segments [Axis]
Warrants (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Exercise Price
Award Exercise Price
Entity Filer Category
Entity Filer Category
Local Phone Number
Local Phone Number
Additional 402(v) Disclosure
Additional 402(v) Disclosure [Text Block]
Other
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Other Item
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Assets
Assets [Abstract]
Underlying Security Market Price Change
Underlying Security Market Price Change, Percent
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
Upfront Payment
Upfront Payment [Member]
Upfront Payment
Forfeitures (in dollars per shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Fair Value Measurements
Fair Value Disclosures [Text Block]
Stockholders’ equity:
Equity, Attributable to Parent [Abstract]
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member]
Non-cash collaboration and license agreement expense
Collaboration And License Agreement, Noncash Expense
Collaboration And License Agreement, Noncash Expense
Entity Address, Address Line One
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, Address Line Two
Research and development
Research and Development Expense
Accumulated Other Comprehensive Gain (Loss)
AOCI Attributable to Parent [Member]
Shares withheld for taxes for vesting of restricted stock units (in shares)
Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation
Non-current portion of operating lease liabilities
Operating Lease, Liability, Noncurrent
Name of Property [Domain]
Name of Property [Domain]
Fair Value as of Grant Date
Award Grant Date Fair Value
Entity Registrant Name
Entity Registrant Name
Stock Price or TSR Estimation Method
Stock Price or TSR Estimation Method [Text Block]
Unaudited Interim Condensed Consolidated Financial Information
Unaudited Interim Condensed Consolidated Financial Information [Policy Text Block]
Unaudited interim condensed consolidated financial information
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Total unrecognized compensation cost related to unvested restricted stock units
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Shares reserved for future awards under the 2024 Inducement Plan
Inducement Plan
Inducement Plan [Member]
Inducement Plan
Number of platforms
Number Of Platforms
Number Of Platforms
Document Quarterly Report
Document Quarterly Report
Assets
Assets, Fair Value Disclosure
Issued (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Issued in Period
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Issued in Period
Number of securities
Debt Securities, Available-for-Sale, Unrealized Loss Position, Number of Positions
Changed Peer Group, Footnote
Changed Peer Group, Footnote [Text Block]
Counterparty Name [Domain]
Counterparty Name [Domain]
Number of operating segments
Number of Operating Segments
Amortization of premiums and discounts on marketable securities, net
Accretion (Amortization) of Discounts and Premiums, Investments
Adjustment To PEO Compensation, Footnote
Adjustment To PEO Compensation, Footnote [Text Block]
Weighted average remaining contractual term outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Title
Trading Arrangement, Individual Title
Peer Group Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Restatement Determination Date:
Restatement Determination Date [Axis]
Non-PEO NEO
Non-PEO NEO [Member]
Aggregate intrinsic value outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Issuance of common stock under employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Percentage of ownership held by sole owner and affiliates
Percentage of Ownership Held by Sole Owner And Affiliates
Percentage of Ownership Held by Sole Owner And Affiliates
Sale of Stock [Axis]
Sale of Stock [Axis]
Name
Trading Arrangement, Individual Name
Number of Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares [Roll Forward]
Award Type [Domain]
Award Type [Domain]
Cash equivalents and debt securities, available-for-sale, accumulated gross unrealized losses, current, before tax
Cash Equivalents And Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Loss, Current, Before Tax
Cash Equivalents And Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Loss, Current, Before Tax
Equity Awards Adjustments
Equity Awards Adjustments [Member]
Pension Benefits Adjustments, Footnote
Pension Benefits Adjustments, Footnote [Text Block]
Disaggregation of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Compensation Amount
Outstanding Recovery Compensation Amount
Schedule Of Common Stock Reserved For Future Issuance [Line Items]
Schedule Of Common Stock Reserved For Future Issuance [Line Items]
Schedule Of Common Stock Reserved For Future Issuance Line items
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Statement of Comprehensive Income [Abstract]
Recovery of Erroneously Awarded Compensation Disclosure [Line Items]
Contract with customer, liability, revenue recognized
Contract with Customer, Liability, Revenue Recognized
MNPI Disclosure Timed for Compensation Value
MNPI Disclosure Timed for Compensation Value [Flag]
Issued (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Issued in Period, Weighted Average Grant Date Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Issued in Period, Weighted Average Grant Date Fair Value
Name
Awards Close in Time to MNPI Disclosures, Individual Name
Unvested beginning balance (in dollars per share)
Unvested ending balance (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Cash equivalents, accumulated gross unrealized gains, current, before tax
Cash Equivalents, Accumulated Gross Unrealized Gain, Current, Before Tax
Cash Equivalents, Accumulated Gross Unrealized Gain, Current, Before Tax
Personnel-related expenses
Other Labor-related Expenses
Elsunersen
Elsunersen [Member]
Elsunersen
Aggregate Erroneous Compensation Not Yet Determined
Aggregate Erroneous Compensation Not Yet Determined [Text Block]
Potential shares issuable under the 2020 ESPP
Employee Stock [Member]
Cash equivalents, at carrying value
Cash Equivalents, at Carrying Value
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Accumulated other comprehensive gain
Accumulated Other Comprehensive Income (Loss), Net of Tax
Milestone payments
Revenue, Remaining Performance Obligation, Variable Consideration Amount
Revenue, Remaining Performance Obligation, Variable Consideration Amount
Aggregate intrinsic value vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Financial Instruments [Domain]
Financial Instruments [Domain]
April 2024 Public Offering
April 2024 Public Offering [Member]
April 2024 Public Offering
Segments [Domain]
Segments [Domain]
Statement of Income Location, Balance [Axis]
Statement of Income Location, Balance [Axis]
Aggregate Pension Adjustments Service Cost
Aggregate Pension Adjustments Service Cost [Member]
Percentage increase in annual base rent
Percentage Increase In Annual Base Rent
Percentage Increase In Annual Base Rent.
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV [Domain]
Commercial paper
Commercial Paper, Not Included with Cash and Cash Equivalents [Member]
Vormatrigine
Vormatrigine [Member]
Vormatrigine
Warrants (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Company Selected Measure Name
Company Selected Measure Name
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-Sale
Preferred stock, $0.0001 par value; 10,000,000 shares authorized and no shares issued or outstanding as of September 30, 2025 and December 31, 2024
Preferred Stock, Value, Issued
Aggregate Available
Trading Arrangement, Securities Aggregate Available Amount
Accounts payable
Accounts Payable, Current
Stock Appreciation Rights (SARs)
Stock Appreciation Rights (SARs) [Member]
All Executive Categories
All Executive Categories [Member]
Stockholders' Equity Note [Abstract]
Stockholders' Equity Note [Abstract]
Common stock, $0.0001 par value; 150,000,000 shares authorized; 21,165,933 shares issued and outstanding as of September 30, 2025, and 19,422,358 shares issued and outstanding as of December 31, 2024
Common Stock, Value, Issued
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Weighted average common shares outstanding, diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Commitments and contingencies (Note 6)
Commitments and Contingencies
Non-GAAP Measure Description
Non-GAAP Measure Description [Text Block]
Entity Small Business
Entity Small Business
One Big Beautiful Bill Act, research and development expense, accelerated deductions
One Big Beautiful Bill Act, Research And Development Expense, Accelerated Deductions
One Big Beautiful Bill Act, Research And Development Expense, Accelerated Deductions
Cash equivalents, fair value disclosure
Cash Equivalents, Fair Value Disclosure
Cash Equivalents, Fair Value Disclosure
Preferred stock, outstanding (in shares)
Preferred Stock, Shares Outstanding
Document Transition Report
Document Transition Report
After one year through five years
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, after Year One Through Five
Cash equivalents, at carrying value and debt securities, available-for-sale, amortized cost
Cash Equivalents, at Carrying Value And Debt Securities, Available-For-Sale, Amortized Cost
Cash Equivalents, at Carrying Value And Debt Securities, Available-For-Sale, Amortized Cost
Underlying Securities
Award Underlying Securities Amount
Stock issuance costs
Stock Issuance Costs
Stock Issuance Costs
Share-based payment award, increase Authorized (in shares)
Share-Based Compensation Arrangement By Share-Based Payment Award, Increase (Decrease) In Shares Authorized
Share-Based Compensation Arrangement By Share-Based Payment Award, Increase (Decrease) In Shares Authorized
Equity Component [Domain]
Equity Component [Domain]
Document Period End Date
Document Period End Date
PEO Actually Paid Compensation Amount
PEO Actually Paid Compensation Amount
Cash, Cash Equivalent, and Marketable Security
Cash, Cash Equivalent, and Marketable Security [Text Block]
Awards Close in Time to MNPI Disclosures, Table
Awards Close in Time to MNPI Disclosures [Table Text Block]
Revenue from Contract with Customer [Abstract]
Weighted average remaining contractual term exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Document Type
Document Type
Level 3
Fair Value, Inputs, Level 3 [Member]
Net Loss per Share
Earnings Per Share [Text Block]
Name
Outstanding Recovery, Individual Name
Pre-Funded Warrant
Pre-Funded Warrant [Member]
Pre-Funded Warrant
Loss Contingencies [Table]
Loss Contingencies [Table]
Additional paid-in capital
Additional Paid in Capital
Sale of stock, volume-weighted average price, duration
Sale Of Stock, Volume-Weighted Average Price, Duration
Sale Of Stock, Volume-Weighted Average Price, Duration
Product and Service [Axis]
Product and Service [Axis]
Proceeds from stock offerings, net of issuance costs
Proceeds from Issuance of Common Stock
All Individuals
All Individuals [Member]
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Number of product candidates
Number Of Product Candidates
Number Of Product Candidates
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Vested and expected to vest (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Name
Forgone Recovery, Individual Name
Total current assets
Assets, Current
Statistical Measurement [Axis]
Statistical Measurement [Axis]
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member]
Proceeds from exercise of stock options and employee stock purchase plan purchases
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised
Shares reserved for future awards under the 2020 Stock Option and Incentive Plan
Twenty Twenty Employee Stock Incentive Plan [Member]
Twenty Twenty Employee Stock Incentive Plan
Reconciliation of cash, cash equivalents and restricted cash:
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation [Abstract]
At-The-Market Offering
At-The-Market Offering [Member]
At-The-Market Offering
Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Amount
Aggregate intrinsic value exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Payments of tax withholdings related to vesting of restricted stock units
Payment, Tax Withholding, Share-Based Payment Arrangement
Peer Group Issuers, Footnote
Peer Group Issuers, Footnote [Text Block]
Office Space in Boston Massachusetts
Office Space in Boston Massachusetts [Member]
Office Space in Boston Massachusetts
Debt securities, available-for-sale, accumulated gross unrealized gains, current, before tax
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, Current, before Tax
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, Current, before Tax
Erroneous Compensation Analysis
Erroneous Compensation Analysis [Text Block]
Current liabilities:
Liabilities, Current [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Sale of stock, value transferred in excess of consideration received
Sale Of Stock, Value Transferred In Excess Of Consideration Received
Sale Of Stock, Value Transferred In Excess Of Consideration Received
Total operating expenses
Operating Expenses
Rule 10b5-1 Arrangement Terminated
Rule 10b5-1 Arrangement Terminated [Flag]
Level 1
Fair Value, Inputs, Level 1 [Member]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Accrued expenses
Increase (Decrease) in Accrued Liabilities
Net loss per share attributable to common stockholders, diluted (in dollars per share)
Earnings Per Share, Diluted
Erroneously Awarded Compensation Recovery
Erroneously Awarded Compensation Recovery [Table]
Interest income
Interest Income, Operating
Title of 12(b) Security
Title of 12(b) Security
Number of shares issued in transaction (in shares)
Number of shares issued in transaction (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Treasury stock (in shares)
Treasury Stock, Common, Shares
Earnings Per Share [Abstract]
Earnings Per Share [Abstract]
Total other income
Nonoperating Income (Expense)
Change in ownership notice, term
Notice of Change, Term
Notice of Change, Term
Sale of stock, shares, aggregate authorized amount (in shares)
Sale Of Stock, Shares, Aggregate Authorized Amount
Sale Of Stock, Shares, Aggregate Authorized Amount
Summary of Antidilutive Securities Excluded From Computation of Earnings Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Marketable securities
Debt securities, available-for-sale, current
Debt Securities, Available-for-Sale, Current
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Accrued Expenses
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Schedule Of Common Stock Reserved For Future Issuance [Table]
Schedule Of Common Stock Reserved For Future Issuance [Table]
Schedule Of Common Stock Reserved For Future Issuance Table
Exercised (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Summary of Restricted Stock Activity
Nonvested Restricted Stock Shares Activity [Table Text Block]
Award Timing Disclosures [Line Items]
Granted (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Measurement Frequency [Domain]
Measurement Frequency [Domain]
Change in unrealized gain (loss) on marketable securities, net of tax
Change in unrealized gain on marketable securities, net of tax
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Common Stock and Preferred Stock
Equity [Text Block]
Net loss
Net loss
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Subsequent Event [Table]
Subsequent Event [Table]
Expiration Date
Trading Arrangement Expiration Date
Long-term liabilities:
Liabilities, Noncurrent [Abstract]
Percentage change in ownership
Change in Percentage of Ownership
Change in Percentage of Ownership
Accrued other expenses
Other Accrued Liabilities, Current
Product Information [Line Items]
Product Information [Line Items]
Property and equipment, net
Property, Plant and Equipment, Net
Segment Reporting Information [Line Items]
Segment Reporting Information [Line Items]
Preferred stock, authorized (in shares)
Preferred Stock, Shares Authorized
Adoption Date
Trading Arrangement Adoption Date
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Net Income [Text Block]
Entity Current Reporting Status
Entity Current Reporting Status
Other early stage assets
Other Early State Assets [Member]
Other Early State Assets
Awards Close in Time to MNPI Disclosures
Awards Close in Time to MNPI Disclosures [Table]
Loss from operations
Operating Income (Loss)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Name of Property [Axis]
Name of Property [Axis]
Financial Instrument [Axis]
Financial Instrument [Axis]
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member]
Executive Category:
Executive Category [Axis]
Current Fiscal Year End Date
Current Fiscal Year End Date
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
Cash equivalents and debt securities, available-for-sale, accumulated gross unrealized gains, current, before tax
Cash Equivalents And Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Gain, Current, Before Tax
Cash Equivalents And Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Gain, Current, Before Tax
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member]
Payables and Accruals [Abstract]
Payables and Accruals [Abstract]
Weighted Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Statement [Table]
Statement [Table]
Other income, net
Other Nonoperating Income (Expense)
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Collaboration and License Agreements
Collaborative Arrangement Disclosure [Text Block]
Cash flows from financing activities:
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Weighted average grant-date fair value per share (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Equity Awards Adjustments, Excluding Value Reported in Compensation Table
Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member]
2020 Employee Stock Incentive Plan
2020 Employee Stock Incentive Plan [Member]
2020 Employee Stock Incentive Plan
Upfront payment
Contract with Customer, Liability
Maturities of marketable securities
Proceeds from Sale and Maturity of Marketable Securities
Reportable Segment
Reportable Segment [Member]
Reportable Segment
Cash and Cash Equivalents [Abstract]
Antidilutive securities (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Shares reserved for future awards under the 2020 Employee Stock Purchase Plan
2020 Employee Stock Purchase Plan
2020 Employee Stock Purchase Plan [Member]
All Adjustments to Compensation
All Adjustments to Compensation [Member]
Amendment Flag
Amendment Flag
Sale of stock (in USD per share)
Sale of Stock, Price Per Share
Number of shares authorized (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Termination Date
Trading Arrangement Termination Date
Net cash provided by financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Adopted [Flag]
Measure:
Measure [Axis]
Summary of Stock Option Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Long-term marketable securities
Debt Securities, Available-for-Sale, Noncurrent
Summary of Financial Assets Measured At Fair Value On A Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Weighted average common shares outstanding, basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Program-specific expenses
Cost of Product and Service Sold
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Number of shares exercisable (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Subsequent Events [Abstract]
Subsequent Events [Abstract]
Segment Reporting [Abstract]
Pay vs Performance Disclosure, Table
Pay vs Performance [Table Text Block]
2017 Stock Incentive Plan
2017 Employee Stock Incentive Plan [Member]
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Other income:
Nonoperating Income (Expense) [Abstract]
Entity Tax Identification Number
Entity Tax Identification Number
Beginning balance (in dollars per share)
Ending balance (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Expense of Enforcement, Amount
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Option Exercise Fee
Option Exercise Fee [Member]
Option Exercise Fee
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Common stock, issued (in shares)
Common Stock, Shares, Issued
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Trading Arrangement:
Trading Arrangement [Axis]
Total Shareholder Return Amount
Total Shareholder Return Amount
Cash equivalents and debt securities, available-for-sale, fair value disclosure
Cash Equivalents And Debt Securities, Available-for-Sale, Fair Value Disclosure
Cash Equivalents And Debt Securities, Available-for-Sale, Fair Value Disclosure
Loss Contingencies [Line Items]
Loss Contingencies [Line Items]
Subsequent Events
Subsequent Events [Text Block]
Insider Trading Arrangements [Line Items]
Security Exchange Name
Security Exchange Name
Cancelled or forfeited (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Total liabilities
Liabilities
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Pension Adjustments Prior Service Cost
Pension Adjustments Prior Service Cost [Member]
Operating expenses:
Operating Expenses [Abstract]
Material Terms of Trading Arrangement
Material Terms of Trading Arrangement [Text Block]
Asset Class [Domain]
Asset Class [Domain]
Issuance of common stock
Stock Issued During Period, Value, New Issues
Statement [Line Items]
Statement [Line Items]
Rule 10b5-1 Arrangement Adopted
Rule 10b5-1 Arrangement Adopted [Flag]
Cash and cash equivalents
Cash and Cash Equivalent
Maximum percentage of voting power
Percentage of Ownership Held by Sole Owner
Percentage of Ownership Held by Sole Owner
Counterparty Name [Axis]
Counterparty Name [Axis]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Common Stock
Common Stock [Member]
Vested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Total
Debt Securities, Available-for-Sale
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Non-NEOs
Non-NEOs [Member]
Corporate debt securities
Corporate Debt Securities [Member]
(Decrease) increase in cash, cash equivalents and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation