Weighted average remaining contractual term vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Statistical Measurement [Domain]
Statistical Measurement [Domain]
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Schedule of Lease cost
Lease, Cost [Table Text Block]
Summary of Cash, Cash Equivalents and Restricted Cash
Cash, Cash Equivalents and Investments [Table Text Block]
Cover [Abstract]
Increase in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Schedule of Lessee, Operating Lease, Liability, Maturity
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Income Tax Jurisdiction [Domain]
Income Tax Jurisdiction [Domain]
License And Collaboration Agreement
License And Collaboration Agreement [Member]
License And Collaboration Agreement
Trading Symbol
Trading Symbol
Segment Reporting Information [Line Items]
Segment Reporting Information [Line Items]
All Trading Arrangements
All Trading Arrangements [Member]
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Net Income [Text Block]
Non-NEOs
Non-NEOs [Member]
Rule 10b5-1 Arrangement Adopted
Rule 10b5-1 Arrangement Adopted [Flag]
Awards Close in Time to MNPI Disclosures
Awards Close in Time to MNPI Disclosures [Table]
Other Commitments [Line Items]
Other Commitments [Line Items]
Pay vs Performance Disclosure [Line Items]
Peer Group Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Tenacia
Tenacia [Member]
Tenacia
Net Loss per Share
Earnings Per Share, Policy [Policy Text Block]
Non-Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Summary of common stock reserved for future issuance
Schedule Of Common Stock Reserved For Future Issuance [Table Text Block]
Schedule Of Common Stock Reserved For Future Issuance
Fair Value of Financial Assets
Fair Value Disclosures [Text Block]
Change in unrealized gain (loss) on marketable securities, net of tax
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Award Timing Disclosures [Line Items]
Debt securities, available-for-sale, accumulated gross unrealized loss, current, before tax
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, Current, before Tax
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, Current, before Tax
Other Performance Measure, Amount
Other Performance Measure, Amount
Common stock, outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
Operating lease cost
Operating Lease, Cost
Class of Warrant or Right [Axis]
Class of Warrant or Right [Axis]
Maturities of marketable securities
Proceeds from Sale and Maturity of Marketable Securities
Non-current portion of operating lease liabilities
Operating Lease, Liability, Noncurrent
Revenue from Contract with Customer [Line Items]
Revenue from Contract with Customer [Abstract]
Current portion of deferred revenue
Contract with Customer, Liability, Current
Plan Name [Domain]
Plan Name [Domain]
Sale of stock, price (in USD per share)
Sale of Stock, Price Per Share
Proceeds from issuance of equity
Proceeds from Issuance or Sale of Equity
Other non-current assets
Other Assets, Noncurrent
Entity Tax Identification Number
Entity Tax Identification Number
Amortization
Deferred Tax Assets, Tax Deferred Expense, Amortization
Deferred Tax Assets, Tax Deferred Expense, Amortization
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Research and development credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
April 2024 Follow-On Offering
April 2024 Follow-On Offering [Member]
April 2024 Follow-On Offering
Money market funds
Money Market Funds [Member]
Other
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Sale of stock, net of discounts, commissions and offering expenses
Sale of Stock, Consideration Received on Transaction
Cash flows from operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Operating loss carryforwards, state and local
Deferred Tax Assets, Operating Loss Carryforwards, State and Local
Plan Name [Axis]
Plan Name [Axis]
Equity Components [Axis]
Equity Components [Axis]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Award Timing Method
Award Timing Method [Text Block]
Research and Development Costs and Patent-Related Costs
Research and Development Expense, Policy [Policy Text Block]
Trading Arrangements, by Individual
Trading Arrangements, by Individual [Table]
Total available-for-sale securities, estimated fair value
Total
Debt Securities, Available-for-Sale
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Insider Trading Policies and Procedures [Line Items]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
2024 Sales Agreement
2024 Sales Agreement [Member]
2024 Sales Agreement
Adjustment to Compensation, Amount
Adjustment to Compensation Amount
Aggregate intrinsic value outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Payables and Accruals [Abstract]
Compensation Amount
Outstanding Recovery Compensation Amount
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member]
Entity Small Business
Entity Small Business
Accrued Expenses
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Company Selected Measure Amount
Company Selected Measure Amount
Tabular List, Table
Tabular List [Table Text Block]
Net deferred tax assets
Deferred Tax Assets, Net
Valuation allowance, increase (decrease), amount
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Level 3
Fair Value, Inputs, Level 3 [Member]
Relutrigine
Relutrigine [Member]
Relutrigine
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
RogCon
RogCon [Member]
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member]
Sale of stock, volume-weighted average price, premium
Sale Of Stock, Volume-Weighted Average Price, Premium
Sale Of Stock, Volume-Weighted Average Price, Premium
Warrants (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Issuance of common stock under employee stock purchase plan (in shares)
Issuance of common stock under employee stock purchase plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Accrued expenses
Total accrued expenses
Accrued Liabilities, Current
Ulixacaltamide
Ulixacaltamide [Member]
Ulixacaltamide
Antidilutive securities excluded from computation of earnings per share (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Cash, cash equivalents and restricted cash, beginning of period
Cash, cash equivalents and restricted cash, end of period
Total cash, cash equivalents and restricted cash
Total cash, cash equivalents and restricted cash as shown on the consolidated statements of cash flows
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Amortization of premiums and discounts on marketable securities, net
Accretion (Amortization) of Discounts and Premiums, Investments
Unrecognized compensation cost related to unvested restricted stock units
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Current assets:
Assets, Current [Abstract]
Payments of tax withholdings related to vesting of restricted stock units
Payment, Tax Withholding, Share-Based Payment Arrangement
Offering costs from in accounts payable / accrued expenses
Stock Issuance Costs Incurred But Not Yet Paid
Stock Issuance Costs Incurred But Not Yet Paid
March Sales Agreement with Jeffries
March Sales Agreement with Jeffries [Member]
March Sales Agreement with Jeffries
Treasury shares (in shares)
Treasury Stock, Common, Shares
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Product and Service [Domain]
Product and Service [Domain]
Shares reserved for exercise of outstanding stock options
Outstanding stock options
Share-Based Payment Arrangement, Option [Member]
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-Sale [Table]
Vested (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Fair Value Disclosures [Abstract]
Depreciation expense
Depreciation
Depreciation
2025
Lessee, Operating Lease, Liability, to be Paid, Year One
License
License [Member]
Antidilutive Security, Excluded EPS Calculation [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Preferred stock, outstanding (in shares)
Preferred Stock, Shares Outstanding
Warrant
Warrant [Member]
Security Exchange Name
Security Exchange Name
Award Type [Axis]
Award Type [Axis]
Corporate debt securities
Corporate Debt Securities [Member]
Weighted average exercise price exercised (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Cash, Cash Equivalents and Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Total liabilities
Liabilities
Weighted average exercise price exercisable (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Unvested Restricted Stock Units
Unvested Restricted Stock Units [Member]
Unvested Restricted Stock Units
Common stock, par value (in USD per share)
Common Stock, Par or Stated Value Per Share
Forgone Recovery, Explanation of Impracticability
Forgone Recovery, Explanation of Impracticability [Text Block]
Commitment
Other Commitment
Schedule of Debt Securities, Available-for-Sale
Debt Securities, Available-for-Sale [Table Text Block]
Research and development
Research and development expense
Research and Development Expense
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Foreign Currency
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Expiration Date
Trading Arrangement Expiration Date
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Current operating lease liabilities
Operating Lease, Liability, Current
Total Shareholder Return Amount
Total Shareholder Return Amount
Common stock, issued (in shares)
Common Stock, Shares, Issued
Accrued personnel-related expenses
Accrued Personnel Related Expenses Current
Accrued Personnel Related Expenses, Current.
Summary of restricted stock activity
Nonvested Restricted Stock Shares Activity [Table Text Block]
Equity Awards Adjustments, Footnote
Equity Awards Adjustments, Footnote [Text Block]
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Computer equipment
Computer Equipment [Member]
January 2024 Public Offering
January 2024 Public Offering [Member]
January 2024 Public Offering
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Adopted [Flag]
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Property and equipment, gross
Property, Plant and Equipment, Gross
Issuance of common stock from exercise of stock options (in shares)
Number of shares exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Named Executive Officers, Footnote
Named Executive Officers, Footnote [Text Block]
Research and development
Research and Development Expense [Member]
Weighted Average Exercise Price per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Common stock, authorized (in shares)
Common Stock, Shares Authorized
Commercial paper
Commercial Paper, Not Included with Cash and Cash Equivalents [Member]
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Weighted average common shares outstanding, diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Accrued external research and development expenses
Accrued External Research And Development Expenses Current
Accrued External Research And Development Expenses, Current.
MNPI Disclosure Timed for Compensation Value
MNPI Disclosure Timed for Compensation Value [Flag]
Total stockholders’ equity
Beginning balance
Ending balance
Equity, Attributable to Parent
Total gross deferred tax assets
Deferred Tax Assets, Gross
Entity Voluntary Filers
Entity Voluntary Filers
Collaboration and License Agreements
Collaborative Arrangement Disclosure [Text Block]
Within one year
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One
Common Stock Warrants
Common Stock Warrants, Policy [Policy Text Block]
Common Stock Warrants, Policy
Property and Equipment, Net
Property, Plant and Equipment Disclosure [Text Block]
Fair Value, Recurring
Fair Value, Recurring [Member]
Number of shares granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Number of shares authorized (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Sale of Stock [Domain]
Sale of Stock [Domain]
Pension Adjustments Prior Service Cost
Pension Adjustments Prior Service Cost [Member]
Document Fiscal Period Focus
Document Fiscal Period Focus
January 2024 Follow-On Offering
January 2024 Follow-On Offering [Member]
January 2024 Follow-On Offering
Off-Balance Sheet Risk
Off-Balance-Sheet Credit Exposure, Policy [Policy Text Block]
All Executive Categories
All Executive Categories [Member]
Changed Peer Group, Footnote
Changed Peer Group, Footnote [Text Block]
Weighted average remaining contractual term outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Assets
Assets [Abstract]
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Document Type
Document Type
Pension Benefits Adjustments, Footnote
Pension Benefits Adjustments, Footnote [Text Block]
Schedule of Segment Reporting Information, by Segment
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Total Shareholder Return Vs Peer Group
Total Shareholder Return Vs Peer Group [Text Block]
Vesting of restricted stock units (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Document Annual Report
Document Annual Report
Letters of credit receivable, noncurrent
Letters of Credit Receivable, Noncurrent
Letters of Credit Receivable, Noncurrent
Weighted average remaining contractual term exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Vested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Subsequent Event [Table]
Subsequent Event [Table]
Maximum
Maximum [Member]
2023 Sales Agreement
2023 Sales Agreement [Member]
2023 Sales Agreement
Follow-On Offering
Follow-On Offering [Member]
Follow-On Offering
Upfront payment
Contract with Customer, Liability
Equity Valuation Assumption Difference, Footnote
Equity Valuation Assumption Difference, Footnote [Text Block]
Number of performance obligations
Number Of Performance Obligations
Number Of Performance Obligations
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Accounts payable
Accounts Payable, Current
Accounting Policies [Abstract]
June 2023 Follow-On Offering
June 2023 Follow-On Offering [Member]
June 2023 Follow-On Offering
Sale of Stock, value transferred
Sale Of Stock, Value Transferred
Sale Of Stock, Value Transferred
Schedule of fair value of stock option awards on the grant date using the Black-Scholes option valuation model
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Fair Value Measurements
Fair Value Measurement, Policy [Policy Text Block]
Current Fiscal Year End Date
Current Fiscal Year End Date
Less: interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Total lease costs
Lease, Cost
Operating lease liabilities
Increase (Decrease) in Operating Lease Liabilities
Increase (Decrease) in Operating Lease Liabilities.
Statistical Measurement [Axis]
Statistical Measurement [Axis]
PEO Name
PEO Name
Class of warrant or right, outstanding (in shares)
Class of Warrant or Right, Outstanding
Non-Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated [Flag]
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Total Compensation Amount
Award Type [Domain]
Award Type [Domain]
Name
Outstanding Recovery, Individual Name
License agreement
Licensing Agreements [Member]
Disaggregation of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Stock-based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Variable lease costs
Variable Lease, Cost
Summary of antidilutive securities excluded from computation of earnings per share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Compensation Actually Paid vs. Company Selected Measure
Compensation Actually Paid vs. Company Selected Measure [Text Block]
Non-PEO NEO
Non-PEO NEO [Member]
Available-for-sale marketable securities
Investments, Fair Value Disclosure
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Award Timing Predetermined
Award Timing Predetermined [Flag]
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
Employee Benefit Plan
Retirement Benefits [Text Block]
Debt securities, available-for-sale, amortized cost, current
Debt Securities, Available-for-Sale, Amortized Cost, Current
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Net loss per share attributable to common stockholders, diluted (in usd per share)
Earnings Per Share, Diluted
Stock issued during period, shares, exercise of warrants
Stock Issued During Period, Shares, Exercise Of Warrants
Stock Issued During Period, Shares, Exercise Of Warrants
Counterparty Name [Domain]
Counterparty Name [Domain]
Non-cash operating lease expense
Operating Lease, Right-of-Use Asset, Periodic Reduction
Name
Measure Name
State
State and Local Jurisdiction [Member]
Entity Interactive Data Current
Entity Interactive Data Current
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Restatement does not require Recovery
Restatement Does Not Require Recovery [Text Block]
Schedule of Operating Lease, Consolidated Balance Sheets
Assets And Liabilities, Lessee [Table Text Block]
Assets And Liabilities, Lessee
Cash, cash equivalents, and short-term investments
Cash, Cash Equivalents, and Short-Term Investments
Number of operating segments
Number of Operating Segments
Retirement Benefits [Abstract]
Deferred tax liabilities:
Deferred Tax Liabilities, Gross [Abstract]
Class of warrants or rights, exercised (in shares)
Class Of Warrants Or Rights, Exercised
Class Of Warrants Or Rights, Exercised
Preferred stock, issued (in shares)
Preferred Stock, Shares Issued
UCB
UCB [Member]
UCB
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Table]
Sale of stock, gross proceeds
Sale of Stock, Consideration Received Per Transaction
Statement [Table]
Statement of Financial Position [Abstract]
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Net deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
Total fair value of restricted stock units vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Proceeds from collaboration arrangement
Proceeds From Collaboration Arrangement
Proceeds From Collaboration Arrangement
Other income:
Nonoperating Income (Expense) [Abstract]
Marketable securities
Debt Securities, Available-for-Sale, Current
Cash equivalents, accumulated gross unrealized loss, current, before tax
Cash Equivalents, Accumulated Gross Unrealized Loss, Current, Before Tax
Cash Equivalents, Accumulated Gross Unrealized Loss, Current, Before Tax
Supplemental disclosures of non-cash activities:
Supplemental Cash Flow Information [Abstract]
Unrecognized compensation expense expected to be recognized
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Capitalized research expenditures
Deferred Tax Asset, In-Process Research and Development
Total other income
Nonoperating Income (Expense)
Statement of Comprehensive Income [Abstract]
License agreement, profit share payments
Licensing Agreements, Profit Share Payments [Member]
Licensing Agreements, Profit Share Payments
Cash equivalents, at carrying value
Cash Equivalents, at Carrying Value
Auditor Firm ID
Auditor Firm ID
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Net cash (used in) provided by investing activities
Net Cash Provided by (Used in) Investing Activities
Loss from operations
Operating Income (Loss)
Income Tax Jurisdiction [Axis]
Income Tax Jurisdiction [Axis]
Non-deductible executive compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Total liabilities and stockholders’ equity
Liabilities and Equity
Other
Other Operating Activities, Cash Flow Statement
Subsequent Events
Subsequent Events [Text Block]
Rule 10b5-1 Arrangement Terminated
Rule 10b5-1 Arrangement Terminated [Flag]
All Adjustments to Compensation
All Adjustments to Compensation [Member]
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Axis]
Marketable Securities
Marketable Securities, Policy [Policy Text Block]
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Additional paid-in capital
Additional Paid in Capital
Commitments and Contingencies Disclosure [Abstract]
Upfront Payment
Upfront Payment [Member]
Upfront Payment
Milestone Payment
Milestone Payment [Member]
Milestone Payment
Non-cash collaboration and license agreement expense
Collaboration And License Agreement, Noncash Expense
Collaboration And License Agreement, Noncash Expense
Underlying Security Market Price Change
Underlying Security Market Price Change, Percent
Ionis
Ionis [Member]
Ionis
Individual:
Individual [Axis]
Shares withheld for taxes for vesting of restricted stock units
Share-Based Payment Arrangement, Decrease for Tax Withholding Obligation
Accumulated Other Comprehensive Gain (Loss)
AOCI Attributable to Parent [Member]
Name of Property [Domain]
Name of Property [Domain]
Weighted average exercise price cancelled or forfeited (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Restricted cash
Restricted Cash
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Debt securities issued by U.S. government agencies
US Government Agencies Debt Securities [Member]
Product and Service [Axis]
Product and Service [Axis]
Entity Address, State or Province
Entity Address, State or Province
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Statement [Line Items]
Statement [Line Items]
Erroneous Compensation Analysis
Erroneous Compensation Analysis [Text Block]
Operating expenses:
Operating Expenses [Abstract]
Schedule of Property, Plant and Equipment
Property, Plant and Equipment [Table Text Block]
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Total Shareholder Return [Text Block]
Available-for-sale securities:
Financial Instruments [Domain]
Weighted average grant date fair value beginning balance (in dollars per share)
Weighted average grant date fair value ending balance (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Shares reserved for future awards under the 2024 Inducement Plan
Inducement Plan [Member]
Inducement Plan
Number of platforms
Number Of Platforms
Number Of Platforms
Restatement Determination Date
Restatement Determination Date
Number of shares vested and expected to vest (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Issued (in shares)
Share-Based Compensation Arrangement By Share-Based Payment Award, Equity Instruments Other Than Options, Issued In Period
Share-Based Compensation Arrangement By Share-Based Payment Award, Equity Instruments Other Than Options, Issued In Period
Long-term marketable securities
Debt Securities, Available-for-Sale, Noncurrent
Adoption Date
Trading Arrangement Adoption Date
Pay vs Performance Disclosure
Pay vs Performance Disclosure [Table]
Related Party Transactions [Abstract]
Non-current portion of deferred revenue
Contract with Customer, Liability, Noncurrent
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Weighted average exercise price beginning balance (in dollars per share)
Weighted average exercise price ending balance (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Erroneously Awarded Compensation Recovery
Erroneously Awarded Compensation Recovery [Table]
Number of shares outstanding beginning balance (in shares)
Number of shares outstanding ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Segments [Axis]
Segments [Axis]
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member]
2024 Employee Stock Incentive Plan
2024 Employee Stock Incentive Plan [Member]
2024 Employee Stock Incentive Plan
Federal statutory income tax rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Property, Plant and Equipment [Abstract]
Exercise Price
Award Exercise Price
Schedule of Deferred Tax Assets and Liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Net Loss per Share
Earnings Per Share [Text Block]
Percentage of ownership held by sole owner and affiliates
Percentage of Ownership Held by Sole Owner And Affiliates
Percentage of Ownership Held by Sole Owner And Affiliates
Arrangement Duration
Trading Arrangement Duration
Office furniture and equipment
Office Furniture and Equipment [Member]
Office Furniture and Equipment
Foreign currency gain (loss)
Foreign Currency Transaction Loss, before Tax
Issuance of common stock under employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Subsequent Event
Subsequent Event [Member]
Issuance of common stock upon exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Federal and state research and development credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Loss on available-for-sale securities
Gain (Loss) on Investments
Cash equivalents and debt securities, available-for-sale, accumulated gross unrealized loss, current, before tax
Cash Equivalents And Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Loss, Current, Before Tax
Cash Equivalents And Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Loss, Current, Before Tax
Name of Property [Axis]
Name of Property [Axis]
Federal
Domestic Tax Jurisdiction [Member]
Income Taxes
Income Tax, Policy [Policy Text Block]
Peer Group Issuers, Footnote
Peer Group Issuers, Footnote [Text Block]
Segments [Domain]
Segments [Domain]
Other debt securities
Other Debt Obligations [Member]
Schedule Of Common Stock Reserved For Future Issuance [Line Items]
Schedule Of Common Stock Reserved For Future Issuance [Line Items]
Schedule Of Common Stock Reserved For Future Issuance Line items
Material Terms of Trading Arrangement
Material Terms of Trading Arrangement [Text Block]
All Individuals
All Individuals [Member]
Issued (in dollars per share)
Share-Based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Issued in Period, Weighted Average Grant Date Fair Value
Share-based compensation arrangement by share-based payment award, equity instruments other than options, issued in period, weighted average grant date fair value
PEO
PEO [Member]
Cash equivalents, accumulated gross unrealized gain, current, before tax
Cash Equivalents, Accumulated Gross Unrealized Gain, Current, Before Tax
Cash Equivalents, Accumulated Gross Unrealized Gain, Current, Before Tax
Income Tax Disclosure [Abstract]
Name
Trading Arrangement, Individual Name
Other income, net
Other Nonoperating Income (Expense)
Elsunersen
Elsunersen [Member]
Elsunersen
Stockholders’ equity:
Statement of Stockholders' Equity [Abstract]
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset [Axis]
Entity Public Float
Entity Public Float
Proceeds from exercise of options and employee stock purchase plan purchases
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised
Personnel-related expenses
Other Labor-related Expenses
Milestone payments
Revenue, Remaining Performance Obligation, Variable Consideration Amount
Revenue, Remaining Performance Obligation, Variable Consideration Amount
Stock-based compensation
Effective Income Tax Rate Reconciliation, Tax Expense (Benefit), Share-Based Payment Arrangement, Percent
April 2024 Public Offering
April 2024 Public Offering [Member]
April 2024 Public Offering
Awards Close in Time to MNPI Disclosures, Table
Awards Close in Time to MNPI Disclosures [Table Text Block]
Other Commitments [Domain]
Other Commitments [Domain]
Percentage increase in annual base rent
Percentage Increase In Annual Base Rent
Percentage Increase In Annual Base Rent.
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Total shares of authorized common stock reserved for future issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member]
Vormatrigine
Vormatrigine [Member]
Vormatrigine
Operating loss carryforwards, not subject to expiration
Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration
Cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Amount
Cash Equivalents and Marketable Securities
Cash, Cash Equivalents, and Marketable Securities [Text Block]
Local Phone Number
Local Phone Number
Less: Valuation allowance
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Aggregate Erroneous Compensation Not Yet Determined
Aggregate Erroneous Compensation Not Yet Determined [Text Block]
Total operating expenses
Operating Expenses
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Weighted Average Remaining Contractual Term and Aggregate Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
PEO Total Compensation Amount
PEO Total Compensation Amount
Long-term liabilities:
Liabilities, Other than Long-Term Debt, Noncurrent [Abstract]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset [Domain]
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Audit Information [Abstract]
Audit Information [Abstract]
Statement of Income Location, Balance [Axis]
Statement of Income Location, Balance [Axis]
Weighted average exercise price vested and expected to vest (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Impairment losses
Impairment, Long-Lived Asset, Held-for-Use
Common Stock
Common Stock [Member]
Measure:
Measure [Axis]
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Asset Class [Domain]
Asset Class [Domain]
Significant Agreements
Significant Agreements [Text Block]
Significant Agreements
Share price (in dollars per share)
Share Price
Cash equivalents, fair value disclosure
Cash Equivalents, Fair Value Disclosure
Cash Equivalents, Fair Value Disclosure
Preferred stock, authorized (in shares)
Preferred Stock, Shares Authorized
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Expense of Enforcement, Amount
Issuance of common stock from at-the-market and follow-on public offerings (in shares)
Stock Issued During Period, Shares, New Issues
Entity Emerging Growth Company
Entity Emerging Growth Company
Cash equivalents, at carrying value and debt securities, available-for-sale, amortized cost
Cash Equivalents, at Carrying Value And Debt Securities, Available-For-Sale, Amortized Cost
Cash Equivalents, at Carrying Value And Debt Securities, Available-For-Sale, Amortized Cost
Stock issuance costs
Stock Issuance Costs
Stock Issuance Costs
Share-based payment award, increase (decrease) Authorized (in shares)
Share-Based Compensation Arrangement By Share-Based Payment Award, Increase (Decrease) In Shares Authorized
Share-Based Compensation Arrangement By Share-Based Payment Award, Increase (Decrease) In Shares Authorized
Segment Reporting [Abstract]
Shares withheld for taxes for vesting of restricted stock units (in shares)
Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation
Entity Central Index Key
Entity Central Index Key
Other segment expenses
Segment Reporting, Other Segment Item, Amount
General and administrative
General and Administrative Expense [Member]
2021 Sales Agreement
2021 Sales Agreement [Member]
2021 Sales Agreement
Non-GAAP Measure Description
Non-GAAP Measure Description [Text Block]
Non-PEO NEO Average Compensation Actually Paid Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Sale of stock, aggregate authorized amount
Sale Of Stock, Aggregate Authorized Amount
Sale Of Stock, Aggregate Authorized Amount
Common Stock and Preferred Stock
Equity [Text Block]
Award Timing, How MNPI Considered
Award Timing, How MNPI Considered [Text Block]
Equity Component [Domain]
Equity Component [Domain]
Preferred stock, par value (in USD per share)
Preferred Stock, Par or Stated Value Per Share
Financial Instrument [Axis]
Financial Instrument [Axis]
Segment Information
Segment Reporting Disclosure [Text Block]
Reconciliation of cash, cash equivalents and restricted cash:
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract]
Additional 402(v) Disclosure
Additional 402(v) Disclosure [Text Block]
Pre-Funded Warrant
Pre-Funded Warrant [Member]
Pre-Funded Warrant
Sale of stock, volume-weighted average price, duration
Sale Of Stock, Volume-Weighted Average Price, Duration
Sale Of Stock, Volume-Weighted Average Price, Duration
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Restricted Stock
Unvested restricted stock units
Restricted Stock [Member]
Entity Shell Company
Entity Shell Company
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Number of Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares [Roll Forward]
Title
Trading Arrangement, Individual Title
Number of product candidates
Number Of Product Candidates
Number Of Product Candidates
June 2023 Public Offering
June 2023 Public Offering [Member]
June 2023 Public Offering
Statement [Table]
Statement [Table]
Leases
Deferred Tax Assets, Operating Lease, Right-Of-Use Asset
Deferred Tax Assets, Operating Lease, Right-Of-Use Asset
Counterparty Name [Axis]
Counterparty Name [Axis]
Measurement Frequency [Domain]
Measurement Frequency [Domain]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
City Area Code
City Area Code
Current liabilities:
Liabilities, Current [Abstract]
Auditor Location
Auditor Location
Accrued expenses
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Shares reserved for future awards under the 2020 Stock Option and Incentive Plan
Twenty Twenty Employee Stock Incentive Plan [Member]
Twenty Twenty Employee Stock Incentive Plan
At-The-Market Offering
At-The-Market Offering [Member]
At-The-Market Offering
Changes in tax rates
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent
Insider Trading Policies and Procedures Not Adopted
Insider Trading Policies and Procedures Not Adopted [Text Block]
Level 1
Fair Value, Inputs, Level 1 [Member]
Stockholders' Equity Note [Abstract]
Office Space In Boston, Massachusetts
Office Space In Boston, Massachusetts [Member]
Office Space In Boston, Massachusetts
Total current assets
Assets, Current
Statement of Cash Flows [Abstract]
Debt securities, available-for-sale, accumulated gross unrealized gain, current, before tax
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, Current, before Tax
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, Current, before Tax
Accrued expenses
Increase (Decrease) in Accrued Liabilities
Sale of stock, value transferred in excess of consideration received
Sale Of Stock, Value Transferred In Excess Of Consideration Received
Sale Of Stock, Value Transferred In Excess Of Consideration Received
Number of shares exercisable (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Schedule of Segment Reporting Information, by Segment [Table]
Schedule of Segment Reporting Information, by Segment [Table]
Weighted average grant-date fair value per share (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Other Commitments [Axis]
Other Commitments [Axis]
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Income Taxes
Income Tax Disclosure [Text Block]
Earnings Per Share [Abstract]
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
General and administrative
General and Administrative Expense
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Aggregate Available
Trading Arrangement, Securities Aggregate Available Amount
Equity Awards Adjustments
Equity Awards Adjustments [Member]
Weighted average incremental borrowing rate
Operating Lease, Weighted Average Discount Rate, Percent
Present value of operating lease liabilities
Total lease liabilities
Operating Lease, Liability
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Notice of change, term
Notice of Change, Term
Notice of Change, Term
Underlying Securities
Award Underlying Securities Amount
Sale of stock, shares, aggregate authorized amount (in shares)
Sale Of Stock, Shares, Aggregate Authorized Amount
Sale Of Stock, Shares, Aggregate Authorized Amount
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Amendment Flag
Amendment Flag
Entity Registrant Name
Entity Registrant Name
Adjustment to Non-PEO NEO Compensation Footnote
Adjustment to Non-PEO NEO Compensation Footnote [Text Block]
Stock Appreciation Rights (SARs)
Stock Appreciation Rights (SARs) [Member]
Schedule Of Common Stock Reserved For Future Issuance [Table]
Schedule Of Common Stock Reserved For Future Issuance [Table]
Schedule Of Common Stock Reserved For Future Issuance Table
Schedule of Restricted Cash and Cash Equivalents
Restrictions on Cash and Cash Equivalents [Table Text Block]
Fair Value as of Grant Date
Award Grant Date Fair Value
Subsequent Events [Abstract]
Aggregate intrinsic value vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Shares sold in follow-on public offering (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Level 2
Fair Value, Inputs, Level 2 [Member]
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV [Domain]
Recovery of Erroneously Awarded Compensation Disclosure [Line Items]
Issuance of common stock from at-the-market and follow-on public offerings
Stock Issued During Period, Value, New Issues
Collaboration Agreements and Revenue Recognition
Collaborative Arrangement, Accounting Policy [Policy Text Block]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Summary of stock-based compensation expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Restatement Determination Date:
Restatement Determination Date [Axis]
Title of 12(b) Security
Title of 12(b) Security
Common stock, $0.0001 par value; 150,000,000 shares authorized; 19,422,358 shares issued and outstanding as of December 31, 2024, and 8,791,877 shares issued and outstanding as of December 31, 2023
Common Stock, Value, Issued
Document Financial Statement Error Correction [Flag]
Document Financial Statement Error Correction [Flag]
Share-Based Payment Arrangement [Abstract]
Cash and cash equivalents
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Change in percentage of ownership
Change in Percentage of Ownership
Change in Percentage of Ownership
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member]
Auditor Name
Auditor Name
Forfeited (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member]
Preferred stock, $0.0001 par value; 10,000,000 shares authorized and no shares issued or outstanding as of December 31, 2024 and December 31, 2023
Preferred Stock, Value, Issued
Other Early State Assets
Other Early State Assets [Member]
Other Early State Assets
Future Share-based Awards
Share-Based Payment Arrangement [Member]
Estimated Useful Life
Property, Plant and Equipment, Useful Life
Total gross deferred tax liabilities
Deferred Tax Liabilities, Gross
Potential shares issuable under the ESPP
Employee Stock [Member]
Net loss per share attributable to common stockholders, basic (in usd per share)
Earnings Per Share, Basic
Accounts payable
Increase (Decrease) in Accounts Payable
Proceeds from stock offerings, net of issuance costs
Proceeds from Issuance of Common Stock
Adjustment To PEO Compensation, Footnote
Adjustment To PEO Compensation, Footnote [Text Block]
Award Timing MNPI Disclosure
Award Timing MNPI Disclosure [Text Block]
Award expiration period
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Operating loss carryforwards, domestic
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Aggregate Pension Adjustments Service Cost
Aggregate Pension Adjustments Service Cost [Member]
Laboratory equipment
Laboratory Equipment [Member]
Laboratory Equipment
Non-deductible items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Compensation Actually Paid vs. Other Measure
Compensation Actually Paid vs. Other Measure [Text Block]
Total current liabilities
Liabilities, Current
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member]
Unrecognized compensation expense related to unvested stock based awards
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Total assets
Assets
Cash equivalents and debt securities, available-for-sale, accumulated gross unrealized gain, current, before tax
Cash Equivalents And Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Gain, Current, Before Tax
Cash Equivalents And Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Gain, Current, Before Tax
Concentrations of Credit Risk and Significant Suppliers and License Agreements
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Program-specific expenses
Cost of Goods and Services Sold
Over-Allotment Option
Over-Allotment Option [Member]
Fair Value, Assets Measured on Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Cash and Cash Equivalents [Abstract]
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Deferred revenue
Deferred Tax Assets, Contract With Customer, Liability
Deferred Tax Assets, Contract With Customer, Liability
Commitments and contingencies (Note 8)
Commitments and Contingencies
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Schedule of Effective Income Tax Rate Reconciliation
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
2020 Employee Stock Incentive Plan
2020 Employee Stock Incentive Plan [Member]
2020 Employee Stock Incentive Plan
Termination Date
Trading Arrangement Termination Date
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
Nature of the Business
Nature of Operations [Text Block]
Class of warrant or right, exercise price of warrants or rights (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Reportable Segment
Reportable Segment [Member]
Reportable Segment
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Collaboration revenue
Revenues
2026
Lessee, Operating Lease, Liability, to be Paid, Year Two
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Shares reserved for future awards under the 2020 Employee Stock Purchase Plan
Twenty Twenty Employee Stock Purchase Plan [Member]
Twenty Twenty Employee Stock Purchase Plan
Entity Address, City or Town
Entity Address, City or Town
Deferred tax assets:
Deferred Tax Assets, Gross [Abstract]
After one year through five years
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, after Year One Through Five
Leases
Lessee, Leases [Policy Text Block]
Summary of stock option activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Aggregate intrinsic value exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Net loss
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Trading Arrangement:
Trading Arrangement [Axis]
Other Commitments [Table]
Other Commitments [Table]
Weighted average exercise price granted (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Pay vs Performance Disclosure, Table
Pay vs Performance [Table Text Block]
Defined contribution plan, employer discretionary contribution amount
Defined Contribution Plan, Employer Discretionary Contribution Amount
Operating lease right-of-use asset
Deferred Tax Liabilities, Operating Lease, Right-Of-Use Asset
Deferred Tax Liabilities, Operating Lease, Right-Of-Use Asset
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Loss Contingencies [Table]
Loss Contingencies [Table]
Equity Awards Adjustments, Excluding Value Reported in Compensation Table
Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member]
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member]
Entity File Number
Entity File Number
2017 Stock Incentive Plan
2017 Employee Stock Incentive Plan [Member]
Twenty Seventeen Employee Stock Incentive Plan
Document Fiscal Year Focus
Document Fiscal Year Focus
Income Statement [Abstract]
Entity Address, Address Line One
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, Address Line Two
Accrued other expenses
Other Accrued Liabilities, Current
Assets
Assets, Fair Value Disclosure
Name
Forgone Recovery, Individual Name
Aggregate intrinsic value exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Weighted average remaining lease term (in years)
Operating Lease, Weighted Average Remaining Lease Term
Document Period End Date
Document Period End Date
Sale of Stock [Axis]
Sale of Stock [Axis]
Award Timing MNPI Considered
Award Timing MNPI Considered [Flag]
Option Exercise Fee
Option Exercise Fee [Member]
Option Exercise Fee
Total future lease payments
Lessee, Operating Lease, Liability, to be Paid
Beginning balance (in shares)
Ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Asset Class [Axis]
Asset Class [Axis]
Insider Trading Arrangements [Line Items]
Restricted Cash
Cash and Cash Equivalents Disclosure [Text Block]
Outstanding Aggregate Erroneous Compensation Amount
Outstanding Aggregate Erroneous Compensation Amount
PEO Actually Paid Compensation Amount
PEO Actually Paid Compensation Amount
Interest income
Interest Income, Operating
Contract with customer, liability, revenue recognized
Contract with Customer, Liability, Revenue Recognized
Cash equivalents and debt securities, available-for-sale, fair value disclosure
Cash Equivalents And Debt Securities, Available-for-Sale, Fair Value Disclosure
Cash Equivalents And Debt Securities, Available-for-Sale, Fair Value Disclosure
Adjustment to Compensation:
Adjustment to Compensation [Axis]
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Number of votes per share
Number Of Votes Per One Share
Number Of Votes Per One Share
Document Transition Report
Document Transition Report
Fair Value, Recurring and Nonrecurring [Table]
Fair Value, Recurring and Nonrecurring [Table]
Accumulated other comprehensive gain
Accumulated Other Comprehensive Income (Loss), Net of Tax
Entity Current Reporting Status
Entity Current Reporting Status
Accumulated Deficit
Retained Earnings [Member]
Restricted cash
Restricted Cash and Cash Equivalents
Pension Adjustments Service Cost
Pension Adjustments Service Cost [Member]
Weighted average common shares outstanding, basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Stock Price or TSR Estimation Method
Stock Price or TSR Estimation Method [Text Block]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Executive Category:
Executive Category [Axis]
Name
Awards Close in Time to MNPI Disclosures, Individual Name
Percentage of ownership held by sole owner
Percentage of Ownership Held by Sole Owner
Percentage of Ownership Held by Sole Owner
Number of shares canceled or forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Entity Filer Category
Entity Filer Category
Upfront payment
Revenue, Remaining Performance Obligation, Amount
Operating loss carryforwards, subject to expiration
Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration
Statement of Income Location, Balance [Domain]
Statement of Income Location, Balance [Domain]
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-Sale
Loss Contingencies [Line Items]
Loss Contingencies [Line Items]
Company Selected Measure Name
Company Selected Measure Name